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Table. Post-exposure prophylaxis for non-immune people exposed to a source that is positive for hepatitis B surface antigen or has an unknown status

Type of exposure Hepatitis B immunoglobulin Vaccine  
Perinatal (exposure of babies during and after birth) (see Infants born to mothers who are hepatitis B surface antigen–positive are recommended to receive both hepatitis B vaccine and HBIG in Recommendations)
  • 100 IU by intramuscular injection
  • Single dose immediately after birth (preferably within 12 hours of birth and certainly within 48 hours)
  • 0.5 mL by intramuscular injection
  • As soon as possible immediately after birth (preferably within 24 hours, no later than 7 days), then at 2, 4 and 6 months of age
  • 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site
Percutaneous, ocular or mucous membrane
  • 0.5 mL or 1 mL (depending on age), by intramuscular injection
  • As soon as possible after exposure (within 7 days), and at 1 and 6 months after 1st dose
  • 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site
Sexual
  • 400 IU by intramuscular injection
  • 100 IU if body weight <30 kg
  • Single dose as soon as possible after exposure, preferably within 72 hours of last sexual contact (but may be up to 14 days)
  • 0.5 mL or 1 mL (depending on age), by intramuscular injection
  • As soon as possible after exposure (within 14 days), and at 1 and 6 months after 1st dose
  • 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site

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Hepatitis B

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