Table. Vaccines that are not routinely recommended in pregnancy: inactivated bacterial vaccines
| Vaccine | Recommendation | Comments |
|---|---|---|
| dT (diphtheria-tetanus) | Not routinely recommended as a dT only vaccine. Pregnant women can receive dT vaccine under certain circumstances, such as to manage a tetanus-prone wound, however depending on timing during pregnancy, a dTpa may be a preferred option (see Pertussis). | Many pregnant women have received tetanus- and diphtheria-containing vaccines, with no increased risk of congenital abnormalities in their fetuses.12-14 See Diphtheria and Tetanus for more details. |
| Cholera (oral) | Not routinely recommended | There are limited data on the safety of oral cholera vaccine in pregnancy.2,15 |
| Hib (Haemophilus influenzae type b) | Not routinely recommended. Pregnant women can receive Hib vaccine if they are at increased risk of Hib disease (eg women with asplenia). | Limited data suggest that Hib vaccination during pregnancy is unlikely to harm the fetus.16 |
| MenB (meningococcal B) or MenACWY (quadrivalent meningococcal conjugate) | Not routinely recommended. Pregnant women can receive meningococcal vaccines if they are at increased risk of the disease (see Meningococcal disease). | There are limited data on the safety of meningococcal conjugate vaccines in pregnancy.17 Where clinically indicated, pregnant women can receive these vaccines.2,18 |
| PCV (pneumococcal conjugate vaccine) - 13vPCV (13-valent pneumococcal conjugate), 15vPCV (15-valent pneumococcal conjugate) or 20vPCV (20-valent pneumococcal conjugate) | Not routinely recommended. Pregnant women can receive pneumococcal conjugate vaccine if they have very high risk of invasive pneumococcal disease (IPD) (eg those who do not have a spleen or evidence of reduced splenic function, or immunocompromised, or have cerebrospinal fluid leak) (see Pneumococcal disease). | No data are available. Vaccination with PCV during pregnancy has not been evaluated, although it is unlikely to result in adverse effects. Women of child-bearing age with known risk factors for IPD (including smokers) can receive the vaccine before pregnancy or as soon as practicable after delivery (see Pneumococcal disease). |
| 23vPPV (23-valent pneumococcal polysaccharide) | Not routinely recommended. Pregnant women can receive 23vPPV if they have very high risk of IPD (eg those who do not have a spleen or evidence of reduced splenic function, or immunocompromised, or have cerebrospinal fluid leak) (see Pneumococcal disease). | Pregnant women have received 23vPPV during clinical trials19 with no evidence of adverse effects. However, data are limited. Women of child-bearing age with known risk factors for IPD (including smokers) can receive the vaccine before pregnancy or as soon as practicable after delivery (see Pneumococcal disease). |
| Q fever | Not routinely recommended | No data available. |
| Typhoid Vi polysaccharide | Not routinely recommended. Pregnant women can receive typhoid Vi polysaccharide vaccine if they are travelling to endemic countries where water quality and sanitation are poor. | No data are available.20 Vaccination with typhoid Vi polysaccharide vaccine during pregnancy has not been directly evaluated, although it is unlikely to result in adverse effects. |
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