People with immunocompromising conditions are recommended to receive 3 doses of HPV vaccine

A 3-dose schedule of 9vHPV vaccine is recommended for people with immunocompromising conditions, regardless of their age when they started vaccination.

This is because their immune response is likely to be lower than for immunocompetent people. They are also more likely to develop a persistent HPV infection and HPV-related disease.^6,7

Immunocompromising conditions include:

• Inborn errors of immunity, including primary immunodeficiency disorders
• HIV infection
• malignancy
• haematopoietic stem cell transplant
• solid organ transplant
• immunosuppressive therapy

People with asplenia or hyposplenia

People without a spleen are not considered at higher risk of persistent HPV infection and disease and are recommended to receive a 1-dose schedule if they are aged 9–25 years. This is the same as individuals with a functioning spleen.

See also Vaccination for people who are immunocompromised.