Table. Vaccinated people: post-exposure rabies prophylaxis based on immune status and exposure category
Vaccinated people have evidence of a completed recommended pre-exposure or post-exposure prophylaxis regimen at any time in the past, or have a documented VNAb (rabies virus neutralising antibody) titre of >0.5 IU per mL at any time in the past. For those with a history of partial immunisation, see Incomplete pre-exposure prophylaxis schedule.
| Immune status | Exposure category | HRIG | Dose 1 (day 0) | Dose 2 (day 3) | Dose 3 (day 7) | Dose 4 (day 14) | Dose 5 (day 28) |
|---|---|---|---|---|---|---|---|
| Immunocompetent | Any category II or III | Not needed | Yes | Yes | Not needed | Not needed | Not needed |
| Mildly or moderately immunocompromised | Any category II or III | Not needed | Yes | Yes | Not needed | Not needed | Not needed |
| Severely immunocompromised | Any category II or III | Not needed | Yes | Yes | Yes | Yes | Yes |
|
HRIG = human rabies immunoglobulin Deviations of a few days from this schedule are probably unimportant.27 For defining the level of immunocompromise, see Definitions and Table. Types of medical conditions and immunosuppressive therapy and associated levels of immunocompromise in Vaccination for people who are immunocompromised. |
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