The example conditions and therapies listed are not exhaustive, and providers may include conditions or therapies similar to those below based on clinical judgement.
Condition
Example conditions or treatments
Haematological malignancies (treated and untreated)
Leukaemia, lymphoma, other lymphoproliferative disorder, plasma cell dyscrasia
Malignancy, solid organ transplantation, autoimmune, and inflammatory conditions currently treated with:
haematopoietic stem cell transplant or CAR-T therapy within the last 24 months
conventional chemotherapy
conventional immunosuppressive agent at significant doses, e.g.:
≥20mg/day of prednisone for ≥14 days in a month
high dose methotrexate ≥20mg per week
azathioprine ≥3.0mg/kg/day
6-mercaptopurine ≥1.5mg/kg/day
mycophenolate ≥1g/day
tacrolimus and other systemic calcineurin inhibitors
sirolimus and other mTOR inhibitors
cyclophosphamide
rituximab or other B-cell, and T-cell, targeted monoclonal antibody
JAK inhibitor or other small molecule targeted therapy
fingolimod or other immunomodulatory drug
eculizumab
monotherapy with infliximab or other anti-TNF alpha monoclonal antibody or anakinra, tocilizumab or other anti-interleukin monoclonal antibody are not considered severely immunocompromising for the purposes of COVID-19 vaccine recommendations
HIV with CD4+ cell count <200
Inborn errors of immunity (primary immunodeficiency)
Severe Combined immunodeficiency (SCID), other combined disorders, humoral, phagocytic disorders, complement defects
