Laboratory workers who work with orthopoxviruses are recommended to receive mpox vaccine
Primary preventive vaccination (PPV) with mpox vaccine (for example MVA-BN) is recommended in a 2-dose schedule for laboratory workers working with orthopoxviruses (e.g. smallpox or monkeypox viruses), identified through local laboratory risk assessments. (See the PHLN Laboratory case definition document). People working in these environments should review their own history of smallpox vaccination, as booster doses may be appropriate for those with new or ongoing risk of exposure to mpox.3
People who are severely immunocompromised should be prioritised to receive the 2nd dose of mpox vaccine as close to (but not before) 28 days after the 1st dose as possible, as part of the PPV schedule.
The details of dosage and administration are outlined in Vaccines, dosage and administration.
Booster dose
Booster doses
People who have previously received a smallpox vaccine are likely to have some residual protection, however, may benefit from receiving a dose of mpox vaccine.
Previously vaccinated laboratory workers with ongoing risk of occupational exposure may be considered for a booster. Boosters should be given at ten-yearly intervals.