Table. Vaccination for people with inborn errors of immunity: non-live vaccines
| Non-live vaccine | Antibody (B-cell) immunodeficiency | T-cell or combined (T- and B-cell) immunodeficiency | Phagocytic and neutrophil disorder | Defect of innate immunity | Complement deficiency |
|---|---|---|---|---|---|
| Cholera (non-live) | Use if indicated | Use if indicated | Use if indicated | Use if indicated | Use if indicated |
| COVID-19 | Severe immunodeficiency: 2-dose schedule and consider a 3rd dose | Severe immunodeficiency: 2-dose schedule and consider a 3rd dose | Follow routine schedule | Follow routine schedule | Follow routine schedule |
| Diphtheria-tetanus-pertussis-containing vaccinea | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule |
| Haemophilus influenzae type bb | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule |
| Hepatitis A | Use if indicated | Use if indicated | Use if indicated | Use if indicated | Use if indicated |
| Hepatitis B | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule |
| Human papillomavirus | 3-dose schedule recommended | 3-dose schedule recommended | 3-dose schedule recommended | 3-dose schedule recommended | Follow routine schedule |
| Influenza (non-live) | Recommended annually | Recommended annually | Recommended annually | Recommended annually | Recommended annually |
| Japanese encephalitis (non-live) | Use if indicated | Use if indicated | Use if indicated | Use if indicated | Use if indicated |
| Meningococcal ACWY | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule | Primary and booster dose recommended |
| Meningococcal B | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule | Primary and booster dose recommended |
| Mpox (live, non-replicating) | Use if indicated | Use if indicated | Use if indicated | Use if indicated | Use if indicated |
| Pneumococcal (conjugate) | Additional dose at 6 months of age (or at diagnosis) | Additional dose at 6 months of age (or at diagnosis) | Additional dose at 6 months of age (or at diagnosis) | Additional dose at 6 months of age (or at diagnosis) | Follow routine schedule |
| Pneumococcal (polysaccharide) for adults aged ≥18 years only | 1st dose 12 months after PCV, with a 2nd dose at least 5 years later | 1st dose 12 months after PCV, with a 2nd dose at least 5 years later | 1st dose 12 months after PCV, with a 2nd dose at least 5 years later | 1st dose 12 months after PCV with a 2nd dose at least 5 years later | Follow routine schedule |
| Poliob | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule | Follow routine schedule |
| Rabies | Use if indicated. Post-exposure vaccination: 5-dose schedule intramuscularly, and possibly HRIG | Use if indicated. Post-exposure vaccination: 5-dose schedule intramuscularly, and possibly HRIG | Use if indicated. Post-exposure vaccination: 5-dose schedule intramuscularly, and possibly HRIG | Use if indicated. Post-exposure vaccination: 5-dose schedule intramuscularly, and possibly HRIG | Use if indicated. |
| Immunisation against respiratory syncytial virus (vaccines or monoclonal antibodies) | 1 dose recommended | 1 dose recommended | 1 dose recommended | 1 dose recommended | Use if indicated |
| Typhoid (non-live) | Use if indicated | Use if indicated | Use if indicated | Use if indicated | Use if indicated |
| Zoster (herpes zoster, recombinant) | 2-dose schedule recommended (1-2 months apart) | 2-dose schedule recommended (1-2 months apart) | 2-dose schedule recommended (1-2 months apart) | 2-dose schedule recommended (1-2 months apart) | Use if indicated |
|
Acronym used: HRIG = human rabies immunoglobulin Footnotes: a Use DTPa for children <10 years of age, and dTpa for those ≥10 years of age. b This may be given as a combined vaccine. |
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