Table. Indications for serological testing following disease exposure to guide post-exposure prophylaxis and management
| Vaccine antigen | Recommendation for serological testing following disease exposure | Link to further information |
|---|---|---|
| Hepatitis B | Testing is recommended if there is a possibility that the individual is not immune (ie unvaccinated, has not completed a full course of hepatitis B vaccination or vaccination is not documented), especially if they do not have prior documented evidence of a protective response (anti-HBs level of ≥10 mIU/mL). | See recommendations for immunisation against hepatitis B for further details |
| Measles | Serological testing may be warranted following exposure to measles infection. Seronegative individuals should receive vaccination with MMR vaccine. | See recommendations for serological testing for public health management of measles. |
| Rabies and other lyssaviruses |
Serological testing is required for some populations to ensure post-exposure management has reached protective levels. Guidance on testing and recommendations for post-exposure management varies based on individual risk, the type of exposure and vaccination history. |
See recommendations for immunisation against rabies and other lyssaviruses for details. |
| Rubella | Serological testing can be considered following exposure to rubella infection if there is no clear documentation of previous vaccination or history of infection. Seronegative individuals should receive vaccination with MMR vaccine. | See recommendations for serological testing for public health management of rubella. |
| Varicella | Serological testing may be considered to guide post-exposure management, especially for immunocompromised people. | See recommendations for serological testing for public health management of varicella. |
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