People with chronic liver disease of any aetiology are recommended to receive hepatitis A vaccine
Hepatitis A vaccination is recommended for people with chronic liver disease of any aetiology, if they are not immune to hepatitis A.2,3 This includes:
- people with chronic liver disease
- people who have received a liver solid organ transplant
- people with chronic hepatitis B
- people with chronic hepatitis C
2 doses are required, with a recommended interval between doses of 6 months.
People with chronic liver disease should receive the vaccine as early in the course of the disease as possible. Immune responses to vaccination in these people can vary — for example:
- people with chronic liver disease of mild to moderate severity mount a good immune response
- people with end-stage liver disease do not respond as well
- liver transplant recipients may not respond at all 4,5
People with chronic hepatitis C or hepatitis B are recommended to receive hepatitis A vaccine because of the high case-fatality rate in this group if they acquire hepatitis A.2
If the person is also at risk of acquiring hepatitis B, they can receive a combination hepatitis A/hepatitis B vaccine. This is usually given in 3 doses. People aged 1 to <16 years can receive a 2-dose schedule using Twinrix 720/20.
For more details, see:
Printed content may be out of date. For up to date information, always refer to the digital version: https://immunisationhandbook.health.gov.au/recommendations/people-with-chronic-liver-disease-of-any-aetiology-are-recommended-to-receive.