A 3-dose schedule of 9vHPV vaccine is recommended for people with severely immunocompromising conditions, regardless of their age when they started vaccination.
This is because their immune response is likely to be lower than for immunocompetent people. They are also more likely to develop a persistent HPV infection and HPV-related disease.6,7
Severely immunocompromising conditions include:
primary or secondary immunodeficiencies (complete or partial deficiencies of B-lymphocyte antibody or T-lymphocytes)
People without a spleen are not considered at higher risk of persistent HPV infection and disease and are recommended to receive a 1-dose schedule if they are aged 9–25 years. This is the same as individuals with a functioning spleen.
