Preterm and low-birthweight infants are recommended to receive 5 doses of hepatitis B vaccine, including a booster dose at 12 months of age
Low-birthweight and preterm newborns do not respond as well to hepatitis B–containing vaccines as full-term infants.12-14
Low-birthweight infants (<2000 g) and/or infants born at <32 weeks gestation (regardless of weight) are recommended to receive a 4-dose schedule at 0 (birth), 2, 4 and 6 months of age, followed by either:
- giving a booster of a hepatitis B–containing vaccine at 12 months of age (without measuring the antibody titre), or
- measuring the level of antibody to hepatitis B surface antigen at 7 months of age; if the antibody titre is <10 mIU per mL, they should receive a booster at 12 months of age (because of a better immunogenic response at this age compared with a younger age)
Printed content may be out of date. For up to date information, always refer to the digital version: https://immunisationhandbook.health.gov.au/recommendations/preterm-and-low-birthweight-infants-are-recommended-to-receive-5-doses-of-hepatitis.