Low-birthweight and preterm newborns do not respond as well to hepatitis B–containing vaccines as full-term infants.12-14
Low-birthweight infants (<2000 g) and/or infants born at <32 weeks gestation (regardless of weight) are recommended to receive a 4-dose schedule at 0 (birth), 2, 4 and 6 months of age, followed by either:
giving a booster of a hepatitis B–containing vaccine at 12 months of age (without measuring the antibody titre), or
measuring the level of antibody to hepatitis B surface antigen at 7 months of age; if the antibody titre is <10 mIU per mL, they should receive a booster at 12 months of age (because of a better immunogenic response at this age compared with a younger age)
The Department of Health and Aged Care acknowledges First Nations peoples as the Traditional Owners of Country throughout Australia, and their continuing connection to land, sea and community. We pay our respects to them and their cultures, and to all Elders both past and present.