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Table. Specified medical conditions associated with increased risk of influenza disease and severe outcomes

Conditions Example medical conditions NIP funded
Cardiac disease
  • Congenital heart disease
  • Congestive heart failure
  • Coronary artery disease
 Yes
Chronic respiratory condition
  • Suppurative lung disease
  • Bronchiectasis
  • Cystic fibrosis
  • Chronic obstructive pulmonary disease
  • Chronic emphysema
  • Severe asthma (requiring frequent medical consultations or the use of multiple medications)
 Yes
Immunocompromising conditions
  • HIV infection
  • Malignancy
  • Immunocompromise due to disease or treatment
  • Asplenia or splenic dysfunction
  • Solid organ transplant
  • Haematopoietic stem cell transplant
  • CAR T-cell therapy
 Yes
Haematological disorder
  • Sickle cell disease or other haemoglobinopathies
 Yes
Chronic metabolic disorder
  • Type 1 or 2 diabetes
  • Amino acid disorders
  • Carbohydrate disorders
  • Cholesterol biosynthesis disorders
  • Fatty acid oxidation defects
  • Lactic acidosis
  • Mitochondrial disorders
  • Organic acid disorders
  • Urea cycle disorders
  • Vitamin/cofactor disorders
  • Porphyrias
 Yes
Chronic kidney disease
  • Chronic renal impairment – eGFR <30 mL/min (stage 4 or 5 disease)
 Yes
Chronic neurological condition
  • Hereditary and degenerative CNS diseases
  • Seizure disorders
  • Spinal cord injuries
  • Neuromuscular disorders
  • Conditions which impair respiratory or airway function
 Yes
Long-term aspirin therapy in children aged 5 to 10 years   Yes
Chronic liver disease
  • Conditions with progressive deterioration of liver function for more than 6 months including cirrhosis and other advanced liver diseases
 No
Obesity
  • Body mass index ≥30 kg per m2
 No
Chromosomal abnormality
  • Trisomy 21 or another chromosomal abnormality that increases the risk of severe disease
 No
Harmful use of alcohol   No
Related diseases
Influenza (flu)
Related chapters
Vaccination for special risk groups

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