Table. Post-exposure prophylaxis for non-immune people exposed to a source that is positive for hepatitis B surface antigen

Type of exposure

Hepatitis B immunoglobulin

Vaccine

Perinatal (exposure of babies during and after birth) (see Infants born to mothers who are hepatitis B surface antigen–positive are recommended to receive both hepatitis B vaccine and HBIG in Recommendations)

• 100 IU by intramuscular injection
• Single dose immediately after birth (preferably within 12 hours of birth and certainly within 48 hours)

• 0.5 mL by intramuscular injection
• As soon as possible immediately after birth (preferably within 24 hours, no later than 7 days), then at 2, 4 and 6 months of age
• 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site

Percutaneous, ocular or mucous membrane

• 400 IU by intramuscular injection
• 100 IU if body weight <30 kg
• Single dose within 72 hours of exposure

• 0.5 mL or 1 mL (depending on age), by intramuscular injection
• As soon as possible after exposure (within 7 days), and at 1 and 6 months after 1st dose
• 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site

Sexual

• 400 IU by intramuscular injection
• 100 IU if body weight <30 kg
• Single dose as soon as possible after exposure, preferably within 72 hours of last sexual contact (but may be up to 14 days)

• 0.5 mL or 1 mL (depending on age), by intramuscular injection
• As soon as possible after exposure (within 14 days), and at 1 and 6 months after 1st dose
• 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site