Table. Recommended intervals between immunoglobulins or blood products, and measles-mumps-rubella, measles-mumps-rubella-varicella or varicella vaccination

Immunoglobulin/blood product	Route	Dose ( or mL)	Dose (estimated mg IgG/kg)	Interval (months)
Blood transfusion: washed red blood cells		10 mL/kg	Negligible	0
Blood transfusion: red blood cells, adenine-saline added		10 mL/kg	10	3
Blood transfusion: packed red blood cells		10 mL/kg	20–60	5
Blood transfusion: whole blood		10 mL/kg	80–100	6
Cytomegalovirus immunoglobulin		3 mL/kg	150	6
Hepatitis B immunoglobulin as hepatitis B prophylaxis		100 or 400	10	3
(intravenous) for treatment of idiopathic thrombocytopenic purpura		na	400	8
(intravenous) for treatment of idiopathic thrombocytopenic purpura		na	1000	10
(intravenous) for treatment of idiopathic thrombocytopenic purpura or Kawasaki disease		na	1600–2000	11
as hepatitis A prophylaxis		0.5 mL (<25 kg), 1.0 mL (25–50 kg), 2.0 mL (>50 kg)	na	3
as measles prophylaxis: standard		0.2 mL/kg (maximum dose 15 mL)	na	5
as measles prophylaxis: immunocompromised		0.5 mL/kg (maximum dose 15 mL)	na	6
Plasma or platelet products		10 mL/kg	160	7
Human rabies immunoglobulin as rabies prophylaxis		20 /kg	22	4
Replacement (or therapy) of immune deficiencies as (intravenous), various doses		na	300–400	9
Rh (D) immunoglobulin (anti-D)		na	na	0
Tetanus immunoglobulin (intramuscular use) as tetanus prophylaxis		250 (given within 24 hours of injury)	10	3
Tetanus immunoglobulin (intramuscular use) as tetanus prophylaxis		500 (>24 hours after injury)	20	3
Zoster immunoglobulin as varicella prophylaxis		200 (0–10 kg), 400 (11–30 kg), 600 (>30 kg)	na	5

= intramuscular; = international units; = intravenous; na = not applicable; = normal human immunoglobulin

Last updated:

5 June 2018

Last reviewed:

5 June 2018

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