Immunoglobulin/blood product

Route

Dose (IU or mL)

Dose (estimated
mg IgG/kg)

Interval (months)

Blood transfusion: washed red blood cells

IV

10 mL/kg

Negligible

0

Blood transfusion: red blood cells, adenine-saline added

IV

10 mL/kg

10

3

Blood transfusion: packed red blood cells

IV

10 mL/kg

20–60

5

Blood transfusion: whole blood

IV

10 mL/kg

80–100

6

Cytomegalovirus immunoglobulin

IV

3 mL/kg

150

6

Hepatitis B immunoglobulin as hepatitis B prophylaxis

IM

100 IU or 400 IU

10

3

NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura

IV

na

400

8

NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura

IV

na

1000

10

NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura or Kawasaki disease

IV

na

1600–2000

11

NHIG as hepatitis A prophylaxis

IM

0.5 mL (<25 kg), 1.0 mL (25–50 kg), 2.0 mL (>50 kg)

na

3

NHIG as measles prophylaxis: standard

IM

0.2 mL/kg (maximum dose 15 mL)

na

5

NHIG as measles prophylaxis: immunocompromised

IM

0.5 mL/kg (maximum dose 15 mL)

na

6

Plasma or platelet products

IV

10 mL/kg

160

7

Human rabies immunoglobulin as rabies prophylaxis

IM

20 IU/kg

22

4

Replacement (or therapy) of immune deficiencies as NHIG (intravenous), various doses

IV

na

300–400

9

Rh (D) immunoglobulin (anti-D)

IM

na

na

0

Tetanus immunoglobulin (intramuscular use) as tetanus prophylaxis

IM

250 IU (given within 24 hours of injury)

10

3

Tetanus immunoglobulin (intramuscular use) as tetanus prophylaxis

IM

500 IU (>24 hours after injury)

20

3

Zoster immunoglobulin as varicella prophylaxis

IM

200 IU (0–10 kg), 400 IU (11–30 kg), 600 IU (>30 kg)

na

5

IM = intramuscular; IU = international units; IV = intravenous; na = not applicable; NHIG = normal human immunoglobulin

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Last updated: 
5 June 2018
Last reviewed: 
5 June 2018

Definitions

IU
international units
IV
intravenous
IM
intramuscular
NHIG
normal human immunoglobulin