Table. Recommended intervals between immunoglobulins or blood products, and measles-mumps-rubella, measles-mumps-rubella-varicella or varicella vaccination
Immunoglobulin/blood product |
Route |
Dose (IU or mL) |
Dose (estimated |
Interval (months) |
Blood transfusion: washed red blood cells |
IV |
10 mL/kg |
Negligible |
0 |
Blood transfusion: red blood cells, adenine-saline added |
IV |
10 mL/kg |
10 |
3 |
Blood transfusion: packed red blood cells |
IV |
10 mL/kg |
20–60 |
5 |
Blood transfusion: whole blood |
IV |
10 mL/kg |
80–100 |
6 |
Cytomegalovirus immunoglobulin |
IV |
3 mL/kg |
150 |
6 |
Hepatitis B immunoglobulin as hepatitis B prophylaxis |
IM |
100 IU or 400 IU |
10 |
3 |
NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura |
IV |
na |
400 |
8 |
NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura |
IV |
na |
1000 |
10 |
NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura or Kawasaki disease |
IV |
na |
1600–2000 |
11 |
NHIG as hepatitis A prophylaxis |
IM |
0.5 mL (<25 kg), 1.0 mL (25–50 kg), 2.0 mL (>50 kg) |
na |
3 |
NHIG as measles prophylaxis: standard |
IM |
0.2 mL/kg (maximum dose 15 mL) |
na |
5 |
NHIG as measles prophylaxis: immunocompromised |
IM |
0.5 mL/kg (maximum dose 15 mL) |
na |
6 |
Plasma or platelet products |
IV |
10 mL/kg |
160 |
7 |
Human rabies immunoglobulin as rabies prophylaxis |
IM |
20 IU/kg |
22 |
4 |
Replacement (or therapy) of immune deficiencies as NHIG (intravenous), various doses |
IV |
na |
300–400 |
9 |
Rh (D) immunoglobulin (anti-D) |
IM |
na |
na |
0 |
Tetanus immunoglobulin (intramuscular use) as tetanus prophylaxis |
IM |
250 IU (given within 24 hours of injury) |
10 |
3 |
Tetanus immunoglobulin (intramuscular use) as tetanus prophylaxis |
IM |
500 IU (>24 hours after injury) |
20 |
3 |
Zoster immunoglobulin as varicella prophylaxis |
IM |
200 IU (0–10 kg), 400 IU (11–30 kg), 600 IU (>30 kg) |
na |
5 |
IM = intramuscular; IU = international units; IV = intravenous; na = not applicable; NHIG = normal human immunoglobulin
Definitions
- IU
- international units
- IV
- intravenous
- IM
- intramuscular
- NHIG
- normal human immunoglobulin
Printed content may be out of date. For up to date information, always refer to the digital version: https://immunisationhandbook.health.gov.au/resources/handbook-tables/table-recommended-intervals-between-immunoglobulins-or-blood-products-and.