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Table. Vaccinated people: post-exposure rabies prophylaxis based on immune status and exposure category

Vaccinated people have evidence of a completed recommended pre-exposure or post-exposure prophylaxis regimen at any time in the past, or have a documented VNAb (rabies virus neutralising antibody) titre of >0.5 IU per mL at any time in the past. For those with a history of partial immunisation, see Incomplete pre-exposure prophylaxis schedule.

Immune status Exposure category HRIG Dose 1 (day 0) Dose 2 (day 3) Dose 3 (day 7) Dose 4 (day 14) Dose 5 (day 28)
Immunocompetent Any category II or III Not needed Yes Yes Not needed Not needed Not needed
Mildly or moderately immunocompromised Any category II or III Not needed Yes Yes Not needed Not needed Not needed
Severely immunocompromised Any category II or III Not needed Yes Yes Yes Yes Yes

HRIG = human rabies immunoglobulin

Deviations of a few days from this schedule are probably unimportant.27

For defining the level of immunocompromise, see Definitions and Table. Types of medical conditions and immunosuppressive therapy and associated levels of immunocompromise in Vaccination for people who are immunocompromised.
Related diseases
Rabies and other lyssaviruses

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