List. Risk conditions for pneumococcal disease

Children and adults with these risk conditions are at increased risk of pneumococcal disease and would benefit from additional doses of pneumococcal vaccine.

Many children and adults with these risk conditions are eligible for funded doses of 13vPCV and 23vPPV under the National Immunisation Program (NIP). However, some people with risk conditions for whom the vaccine is recommended are not eligible to receive funded vaccine doses. This is because the incidence of pneumococcal disease for these risk conditions is not sufficient to meet cost-effectiveness thresholds.

Vaccine doses for people with the risk conditions in this list are funded under the NIP unless otherwise noted. See also Vaccination for people who are immunocompromised for more recommendations for people who are immunocompromised, including specific revaccination recommendations for haematopoietic stem cell transplant recipients.

Risk conditions at increased risk of pneumococcal disease
Previous episode of invasive pneumococcal disease Functional or anatomical asplenia, including sickle cell disease or other haemoglobinopathies congenital or acquired asplenia (for example, splenectomy) or hyposplenia Immunocompromising conditions, including congenital or acquired immune deficiency, including symptomatic IgG subclass or isolated IgA deficiency haematological malignancies solid organ transplant haematopoietic stem cell transplant HIV infection immunosuppressive therapy, where sufficient immune reconstitution for vaccine response is expected; this includes those with underlying conditions requiring but not yet receiving immunosuppressive therapy^a non-haematological malignancies receiving chemotherapy or radiotherapy (currently or anticipated)^a Proven or presumptive cerebrospinal fluid (CSF) leak, including cochlear implants intracranial shunts Chronic respiratory disease, including^b suppurative lung disease, bronchiectasis and cystic fibrosis chronic lung disease in preterm infants chronic obstructive pulmonary disease (COPD) and chronic emphysema^a severe asthma (defined as requiring frequent hospital visits or the use of multiple medications)^a interstitial and fibrotic lung disease^a Chronic renal disease relapsing or persistent nephrotic syndrome chronic renal impairment – eGFR <30 mL/min (stage 4 disease)^c Cardiac disease, including ^b congenital heart disease^d coronary artery disease^d heart failure^d Children born less than 28 weeks gestation^d Trisomy 21^d Chronic liver disease, including^b chronic hepatitis^a cirrhosis^a biliary atresia^a Diabetes^a Smoking (current or in the immediate past)^a Harmful use of alcohol (consuming on average ≥60 g of alcohol (6 Australian standard drinks) per day for males and ≥40 g of alcohol (4 Australian standard drinks) per day for females)^a
Footnotes: a. Not funded under the NIP b. Individual conditions listed beneath or those that are similar based on clinical judgment c. Funded under the NIP for eGFR <15 mL/min only (including patients on dialysis) d. Funded under the NIP for children <5 years only

Risk conditions at increased risk of pneumococcal disease

Previous episode of invasive pneumococcal disease
Functional or anatomical asplenia, including
- sickle cell disease or other haemoglobinopathies
- congenital or acquired asplenia (for example, splenectomy) or hyposplenia
Immunocompromising conditions, including
- congenital or acquired immune deficiency, including symptomatic IgG subclass or isolated IgA deficiency
- haematological malignancies
- solid organ transplant
- haematopoietic stem cell transplant
- HIV infection
- immunosuppressive therapy, where sufficient immune reconstitution for vaccine response is expected; this includes those with underlying conditions requiring but not yet receiving immunosuppressive therapy^a
- non-haematological malignancies receiving chemotherapy or radiotherapy (currently or anticipated)^a
Proven or presumptive cerebrospinal fluid (CSF) leak, including
- cochlear implants
- intracranial shunts
Chronic respiratory disease, including^b
- suppurative lung disease, bronchiectasis and cystic fibrosis
- chronic lung disease in preterm infants
- chronic obstructive pulmonary disease (COPD) and chronic emphysema^a
- severe asthma (defined as requiring frequent hospital visits or the use of multiple medications)^a
- interstitial and fibrotic lung disease^a
Chronic renal disease
- relapsing or persistent nephrotic syndrome
- chronic renal impairment – eGFR <30 mL/min (stage 4 disease)^c
Cardiac disease, including ^b
- congenital heart disease^d
- coronary artery disease^d
- heart failure^d
Children born less than 28 weeks gestation^d
Trisomy 21^d
Chronic liver disease, including^b
- chronic hepatitis^a
- cirrhosis^a
- biliary atresia^a
Diabetes^a
Smoking (current or in the immediate past)^a
Harmful use of alcohol (consuming on average ≥60 g of alcohol (6 Australian standard drinks) per day for males and ≥40 g of alcohol (4 Australian standard drinks) per day for females)^a

Footnotes:

a. Not funded under the NIP
b. Individual conditions listed beneath or those that are similar based on clinical judgment
c. Funded under the NIP for eGFR <15 mL/min only (including patients on dialysis)
d. Funded under the NIP for children <5 years only

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Last updated

11 May 2023

Last reviewed

11 May 2023

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List. Risk conditions for pneumococcal disease

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