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Table. Severely immunocompromising conditions (Ref 7-23) for which additional doses of COVID-19 vaccine are recommended

The example conditions and therapies listed are not exhaustive, and providers may include conditions or therapies similar to those below based on clinical judgement.

Condition Example conditions or treatments
Haematological malignancies (treated and untreated) Leukaemia, lymphoma, other lymphoproliferative disorder, plasma cell dyscrasia
Malignancy, solid organ transplantation, autoimmune, and inflammatory conditions currently treated with:
  • haematopoietic stem cell transplant or CAR-T therapy within the last 24 months
  • conventional chemotherapy
  • conventional immunosuppressive agent at significant doses, e.g.: 
    • ≥20mg/day of prednisone for ≥14 days in a month
    • high dose methotrexate ≥20mg per week
    • azathioprine ≥3.0mg/kg/day
    • 6-mercaptopurine ≥1.5mg/kg/day
    • mycophenolate ≥1g/day
    • tacrolimus and other systemic calcineurin inhibitors
    • sirolimus and other mTOR inhibitors
    • cyclophosphamide
  • rituximab or other B-cell, and T-cell, targeted monoclonal antibody
     
  • JAK inhibitor or other small molecule targeted therapy
  • fingolimod or other immunomodulatory drug
  • eculizumab
  • monotherapy with infliximab or other anti-TNF alpha monoclonal antibody or anakinra, tocilizumab or other anti-interleukin monoclonal antibody are not considered severely immunocompromising for the purposes of COVID-19 vaccine recommendations
HIV with CD4+ cell count <200  
Inborn errors of immunity (primary immunodeficiency) Severe Combined immunodeficiency (SCID), other combined disorders, humoral, phagocytic disorders, complement defects
Chronic kidney disease on dialysis  
Related diseases
COVID-19

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