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Table. Specified medical conditions associated with increased risk of influenza disease and severe outcomes

Conditions	Example medical conditions	NIP funded
Cardiac disease	Congenital heart disease Congestive heart failure Coronary artery disease	Yes
Chronic respiratory condition	Suppurative lung disease Bronchiectasis Cystic fibrosis Chronic obstructive pulmonary disease Chronic emphysema Severe asthma (requiring frequent medical consultations or the use of multiple medications)	Yes
Immunocompromising condition	HIV infection Malignancy Immunocompromise due to disease or treatment Asplenia or splenic dysfunction Solid organ transplant Haematopoietic stem cell transplant CAR T-cell therapy	Yes
Haematological disorder	Sickle cell disease or other haemoglobinopathies	Yes
Chronic metabolic disorder	Type 1 or 2 diabetes Amino acid disorders Carbohydrate disorders Cholesterol biosynthesis disorders Fatty acid oxidation defects Lactic acidosis Mitochondrial disorders Organic acid disorders Urea cycle disorders Vitamin/cofactor disorders Porphyrias	Yes
Chronic kidney disease	Chronic renal impairment – eGFR <30 mL/min (stage 4 or 5 disease)	Yes
Chronic neurological condition	Hereditary and degenerative CNS diseases Seizure disorders Spinal cord injuries Neuromuscular disorders Conditions which impair respiratory or airway function	Yes
Long-term aspirin therapy in children aged 5 to 10 years		Yes
Chronic liver disease	Conditions with progressive deterioration of liver function for more than 6 months including cirrhosis and other advanced liver diseases	No
Obesity	Body mass index ≥30 kg per m²	No
Chromosomal abnormality	Trisomy 21 or another chromosomal abnormality that increases the risk of severe disease	No
Harmful use of alcohol		No

Page history

Last updated

13 March 2026

Last reviewed

13 March 2026

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