Table. Administration of non-live and live vaccines to infants exposed to biological immunosuppressive therapies in utero
| Age | Recommendation for infants exposed to biological therapies excluding anti-CD20 therapies in utero | Recommendation for infants exposed to anti-CD20 therapies, such as rituximab | ||
|---|---|---|---|---|
| Non-live vaccine | Live vaccine | Non-live vaccine | Live vaccine | |
| <6 months |
Give all non-live vaccines according to the routine schedule. Give a single dose of nirsevimab if mother was taking severely immunosuppressive therapies during pregnancy. |
Give rotavirus vaccine according to the routine schedule. Do not give BCG vaccine or other live vaccines. |
Give all non-live vaccines according to the routine schedule. Give a single dose of nirsevimab if mother was taking severely immunosuppressive therapies during pregnancy. |
Do not give rotavirus vaccine to these infants at any gestational age. Do not give any other live vaccines. |
| ≥6 months | Give all non-live vaccines according to the routine schedule | Give live vaccines as scheduled, including BCG vaccine or measles-containing vaccine, if indicated for certain circumstances (e.g. before overseas travel). |
Give all non-live vaccines according to the routine schedule Give an additional dose of 20vPCV at age 6 months. |
Give live vaccines as scheduled, including BCG vaccine if indicated. Do not give rotavirus vaccine, as the infant will be above the recommended age of administration. |
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