Table. Example conditions associated with increased risk of severe outcomes from COVID-19
This table is not exhaustive, and providers should use their judgement to vaccinate people with conditions not listed.
| Condition | Example medical condition |
|---|---|
| Immunocompromising condition | Immunocompromise due to disease or treatment, asplenia or splenic dysfunction, HIV infection, malignancy, solid organ transplant, haematopoietic stem cell transplant, CAR T-cell therapy *Individuals with severe immunocompromise are recommended additional COVID-19 vaccines doses. See Table. Severely immunocompromising conditions for which additional doses of COVID-19 vaccine are recommended. |
| Cardiac disease | Congenital heart disease, congestive heart failure, coronary artery disease |
| Chronic respiratory condition | Severe asthma (requiring frequent medical consultations or the use of multiple medications), cystic fibrosis, bronchiectasis, suppurative lung disease, chronic obstructive pulmonary disease, chronic emphysema |
| Chronic neurological condition | Hereditary and degenerative CNS disease, seizure disorder, spinal cord injury, neuromuscular disorder, conditions which impair respiratory or airway function |
| Chronic metabolic condition | Type 1 or 2 diabetes, amino acid disorder, carbohydrate disorder, cholesterol biosynthesis disorder, fatty acid oxidation defect, lactic acidosis, mitochondrial disorder, organic acid disorder, urea cycle disorder, vitamin/cofactor disorder, porphyria |
| Chronic kidney disease | Chronic renal impairment – eGFR <30 mL/min (stage 4 or 5) |
| Haematological disorder | Sickle cell disease or other haemoglobinopathy |
| Chronic liver disease | Conditions with progressive deterioration of liver function for more than 6 months, including cirrhosis and other advanced liver diseases |
| Chromosomal abnormality | Trisomy 21 or other genetic condition that increases the risk of severe disease |
| Obesity | Body mass index ≥30 kg per m2 |
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