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Table. Post-exposure prophylaxis for non-immune people exposed to a source that is positive for hepatitis B surface antigen

Type of exposure	Hepatitis B immunoglobulin	Vaccine
Perinatal (exposure of babies during and after birth) (see Infants born to mothers who are hepatitis B surface antigen–positive are recommended to receive both hepatitis B vaccine and HBIG in Recommendations)	100 IU by intramuscular injection Single dose immediately after birth (preferably within 12 hours of birth and certainly within 48 hours)	0.5 mL by intramuscular injection As soon as possible immediately after birth (preferably within 24 hours, no later than 7 days), then at 2, 4 and 6 months of age 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site
Percutaneous, ocular or mucous membrane	400 IU by intramuscular injection 100 IU if body weight <30 kg Single dose within 72 hours of exposure	0.5 mL or 1 mL (depending on age), by intramuscular injection As soon as possible after exposure (within 7 days), and at 1 and 6 months after 1st dose 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site
Sexual	400 IU by intramuscular injection 100 IU if body weight <30 kg Single dose as soon as possible after exposure, preferably within 72 hours of last sexual contact (but may be up to 14 days)	0.5 mL or 1 mL (depending on age), by intramuscular injection As soon as possible after exposure (within 14 days), and at 1 and 6 months after 1st dose 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site

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Last updated

5 June 2018

Last reviewed

5 June 2018

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https://immunisationhandbook.health.gov.au/resources/tables/table-post-exposure-prophylaxis-for-non-immune-people-exposed-to-a-source-that-is-positive-for-hepatitis-b-surface-antigen

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