You are here Home Resources Handbook tables Handbook tables Table. Post-exposure prophylaxis for non-immune people exposed to a source that is positive for hepatitis B surface antigen or has an unknown status Listen Print Share Twitter Facebook Email Type of exposure Hepatitis B immunoglobulin Vaccine Perinatal (exposure of babies during and after birth) (see Infants born to mothers who are hepatitis B surface antigen–positive are recommended to receive both hepatitis B vaccine and HBIG in Recommendations) 100 IU by intramuscular injection Single dose immediately after birth (preferably within 12 hours of birth and certainly within 48 hours) 0.5 mL by intramuscular injection As soon as possible immediately after birth (preferably within 24 hours, no later than 7 days), then at 2, 4 and 6 months of age 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site Percutaneous, ocular or mucous membrane 400 IU by intramuscular injection 100 IU if body weight <30 kg Single dose within 72 hours of exposure 0.5 mL or 1 mL (depending on age), by intramuscular injection As soon as possible after exposure (within 7 days), and at 1 and 6 months after 1st dose 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site Sexual 400 IU by intramuscular injection 100 IU if body weight <30 kg Single dose as soon as possible after exposure, preferably within 72 hours of last sexual contact (but may be up to 14 days) 0.5 mL or 1 mL (depending on age), by intramuscular injection As soon as possible after exposure (within 14 days), and at 1 and 6 months after 1st dose 1st dose can be given at the same time as hepatitis B immunoglobulin at a separate site Related diseases Hepatitis B Page history Last updated 30 June 2023 Last reviewed 30 June 2023 Is there anything wrong with this page? Help us improve the Australian Immunisation Handbook What you were doing? (required) What went wrong? (required) Leave this field blank
