Table. Recommendations for revaccination after haematopoietic stem cell transplant in children and adults
These recommendations are regardless of previous vaccination history. Young children may need extra doses of certain vaccines in addition to those in this table. Young children should complete the recommended age-based vaccination schedule after completing the primary post-HSCT vaccination doses in this table. See the relevant disease-specific chapters in this Handbook for details.
Vaccine | 6 months after HSCT | 8 months after HSCT | 12 months after HSCT | 24 months after HSCT | Comments |
---|---|---|---|---|---|
DTPa (diphtheria-tetanus-pertussis)–containing vaccine for children <10 years of age and dTpa for those ≥10 years of age | Yes | Yes | Yes | Not needed |
|
Hib (Haemophilus influenzae type b) vaccine | Yes | Yes | Yes | Not needed |
None |
Hepatitis B vaccine | Yes | Yes | Yes | Not needed |
|
9vHPV (9-valent human papillomavirus vaccine | No | Yes | Yes (see comments) | Yes (see comments) |
|
IPV (inactivated poliovirus) vaccine | Yes | Yes | Yes | Not needed |
A 3-dose course of IPV vaccine is recommended. This can be given as DTPa-IPV or dTpa-IPV ( see ‘DTPa’ above). |
Influenza vaccine | Yes (2 doses in 1st year after transplant, then 1 dose every year after that) | Yes (if not received already) | Yes (if not received already) | Yes |
|
MMR (measles-mumps-rubella) vaccine | No | No | No | Yes (1 or 2 doses with a minimum interval of 4 weeks; see comments) |
|
MenB (meningococcal B) vaccine | Yes | Yes | Not needed (see comments) | Not needed (see comment) |
|
MenACWY (quadrivalent meningococcal conjugate) vaccine | Yes | Yes | Not needed (see comments) | Not needed (see comment) |
The number of doses depends on the person’s age. See Table. Recommendations for MenACWY vaccine for people with a specified medical condition that increases their risk of invasive meningococcal disease in Meningococcal disease. |
PCV (pneumococcal conjugate vaccine) - 13vPCV, 15vPCV [if ≥18 years of age] or 20vPCV [if ≥18 years of age] | Yes | Yes | Yes | Not needed |
See Pneumococcal disease. |
23vPPV (23-valent pneumococcal polysaccharide vaccine) | No | No | No | Yes (2 doses after 13vPCV, 15vPCV or 20vPCV) |
See also Pneumococcal disease. |
Varicella vaccine | No | No | No | Yes (2 doses separated by a minimum interval of 4 weeks; see comments) | Seronegative people should receive 2 doses of varicella vaccine if they:
|
Recombinant zoster vaccine (Shingrix) | Yes | Yes | Not needed | Not needed | Shingrix is recommended for those aged ≥18 years who are immunocompromised. |
Sources: Tomblyn et al,24 Ljungman et al,25 Kumar et al,32 Cordonnier et al,33 Meisel et al,34 Centers for Disease Control and Prevention,35 Ljungman et al36