Table. Recommendations for vaccination after haematopoietic stem cell transplant in children and adults
Vaccine category | Vaccine | Time to start revaccination | Recommended dosing schedule | Minimum dose interval | Comments |
---|---|---|---|---|---|
Non-live vaccines | COVID-19 | 3–6 months after HSCT |
|
4 weeks | Individual risk assessment based on age and presence of other risk factors for severe illness from COVID-19. |
Diphtheria-tetanus-pertussis-containing vaccinea,b,c | 6 months after HSCT |
|
4 weeks | – | |
Haemophilus influenzae type bc,d | 6 months after HSCT | 3-dose schedule | 4 weeks | – | |
Hepatitis A | 6 months after HSCT if indicated based on individual risk exposure | Not routinely recommended, but may be given to HSCT recipients based on increased risk of exposure or severe outcomes from disease | 4 weeks | See also Vaccination for international travellers. | |
Hepatitis Bd | 6 months after HSCT | 3-dose schedule | 1–2 months between dose 1 and dose 2, and 3 months between dose 2 and dose 3 |
|
|
Human papillomavirusd | 6 months after HSCT in people aged >9 years, although enhanced immune responses may be obtained when administered >12months after HSCT | 3-dose schedule | 1-2 months between dose 1 and dose 2, and 4 months between dose 2 and dose 3 | For people aged >25 years, conduct a risk assessment to determine their need for vaccination | |
Influenza | 3–6 months after HSCT |
|
4 weeks | – | |
Japanese encephalitis (inactivated) | 6 months after HSCT if indicated | Not routinely recommended, but may be given to HSCT recipients based on increased risk of exposure or severe outcomes from disease | 4 weeks | See also Vaccination for international travellers. | |
Meningococcal (MenACWY and MenB)d | 6 months after HSCT |
|
|
|
|
Mpox (live, non-replicating) | 6 months after HSCT if indicated based on individual risk exposure | Not routinely recommended, but may be given to HSCT recipients based on increased risk of exposure or severe outcomes from disease | 4 weeks | – | |
Pneumococcal | PCV starts from 3–6 months after HSCT |
|
1 month between PCV doses if aged <12 months, and 2 months if aged ≥12 months | If a person receives a dose of 21vPCV as their PCV dose, the subsequent doses of 23vPPV are not required. | |
Polioc,d | 6 months after HSCT | 3-dose schedule | 4 weeks | A 10-yearly booster dose is recommended for people with ongoing polio exposure. See also Vaccination for international travellers | |
Rabies | 6 months after HSCT if indicated based on individual risk exposure |
|
– | See also Vaccination for international travellers | |
Immunisation against respiratory syncytial virusd | 3–6 months after HSCT |
|
– | – | |
Zoster (herpes zoster, recombinant) | 6 months after HSCT in people aged >18 years | 2-dose schedule | 4 weeks | Consideration can be given to delaying the timing of each dose (e.g. dose 1 at 7 months and dose 2 at 9 months after HSCT), taking into account the person’s transplant type, ongoing treatment (including antiviral prophylaxis) and preference for receiving multiple vaccines at one visit. | |
Live vaccines | BCG | Contraindicated | – | – | BCG is not recommended after HSCT. |
Cholera (live) | Contraindicated | – | – |
|
|
Japanese encephalitis (live) | Contraindicated | – | – |
|
|
Measles-mumps-rubellad,e | 24 months after HSCT, once cell-mediated immunity has reconstituted and no chronic GVHD | 2-dose schedule | 4 weeks |
|
|
Q fever | Contraindicated or consult a specialist | – | – | Serological and skin tests are needed before vaccination. | |
Rotavirus | Contraindicated | – | – | Rotavirus vaccination is contraindicated after HSCT. | |
Typhoid (live) | Contraindicated | – | – |
|
|
Varicella (monovalent)d,e | 24 months after HSCT, once cell-mediated immunity has reconstituted and no chronic GVHD | 2-dose schedule | 4 weeks | Serological testing after revaccination is not recommended, due to poor sensitivity of commercially available assays and the potential for false negative results.39 | |
Yellow fever | 24 months after HCST if indicated based on individual risk exposure | Not routinely recommended, but may be given to HSCT recipients based on increased risk of exposure or severe outcomes from disease | – | See also Vaccination for international travellers | |
Acronyms used:
Footnotes: Sources: Tomblyn et al,20 Ljungman et al,15 Kumar et al,13 Cordonnier et al,14 Meisel et al,16 Centers for Disease Control and Prevention40 |
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