Table. Recommended intervals between immunoglobulins or blood products, and measles-mumps-rubella, measles-mumps-rubella-varicella or varicella vaccination
| Immunoglobulin/blood product | Route | Dose (IU or mL) | Dose (estimated mg IgG/kg) |
Interval (months) |
|---|---|---|---|---|
| Blood transfusion: washed red blood cells | IV | 10 mL/kg | Negligible | 0 |
| Blood transfusion: red blood cells, adenine-saline added | IV | 10 mL/kg | 10 | 3 |
| Blood transfusion: packed red blood cells | IV | 10 mL/kg | 20–60 | 5 |
| Blood transfusion: whole blood | IV | 10 mL/kg | 80–100 | 6 |
| Cytomegalovirus immunoglobulin | IV | 3 mL/kg | 150 | 6 |
| Hepatitis B immunoglobulin as hepatitis B prophylaxis | IM | 100 IU or 400 IU | 10 | 3 |
| NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura | IV | na | 400 | 8 |
| NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura | IV | na | 1000 | 10 |
| NHIG (intravenous) for treatment of idiopathic thrombocytopenic purpura or Kawasaki disease | IV | na | 1600–2000 | 11 |
| NHIG as hepatitis A prophylaxis | IM | 0.5 mL (<25 kg), 1.0 mL (25–50 kg), 2.0 mL (>50 kg) | na | 3 |
| NHIG as measles prophylaxis: standard | IM | 0.2 mL/kg (maximum dose 15 mL) | na | 5 |
| NHIG as measles prophylaxis: immunocompromised | IM | 0.5 mL/kg (maximum dose 15 mL) | na | 6 |
| Plasma or platelet products | IV | 10 mL/kg | 160 | 7 |
| Human rabies immunoglobulin as rabies prophylaxis | IM | 20 IU/kg | 22 | 4 |
| Replacement (or therapy) of immune deficiencies as NHIG (intravenous), various doses | IV | na | 300–400 | 9 |
| Rh (D) immunoglobulin (anti-D) | IM | na | na | 0 |
| Tetanus immunoglobulin (intramuscular use) as tetanus prophylaxis | IM | 250 IU (given within 24 hours of injury) | 10 | 3 |
| Tetanus immunoglobulin (intramuscular use) as tetanus prophylaxis | IM | 500 IU (>24 hours after injury) | 20 | 3 |
| Zoster immunoglobulin as varicella prophylaxis | IM | 200 IU (0–10 kg), 400 IU (11–30 kg), 600 IU (>30 kg) | na | 5 |
Acronyms used:
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