Table. Vaccines that are not recommended in pregnancy
| Vaccine | Recommendation | Comments |
|---|---|---|
| HPV (human papillomavirus) (inactivated viral vaccine) | Not recommended |
Clinical trials and limited data from observational studies where HPV vaccine was inadvertently given during pregnancy indicate that there is no increased risk of adverse effects on the fetus.36-38 If a woman becomes pregnant during a course of HPV vaccination, stop the course and complete it after birth. |
| Influenza (live attenuated viral vaccine) | Not recommended |
Inactivated influenza vaccines should be given in pregnancy instead of LAIV. However, there is no evidence of risk associated with LAIV in pregnancy. The live viruses in LAIV have been attenuated and adapted to cold, allowing them to only replicate at the lower temperatures found in the nasal passage. They cannot replicate efficiently anywhere else in the body and there is therefore no theoretical basis for concern about infection of the unborn foetus or the mother’s lungs. It is not necessary to specifically ask about or test for pregnancy when offering LAIV or to advise avoidance of pregnancy in those who have been recently vaccinated. |
| Yellow fever (live attenuated viral vaccine) | Not recommended | Advise pregnant women against going to rural areas where yellow fever is endemic. However, if travel to a country with a risk of yellow fever virus transmission is unavoidable, pregnant women should receive yellow fever vaccine.2,39,40 Many pregnant women have received yellow fever vaccine with no adverse outcomes,41 however there have been case reports of transmission to infants during pregnancy. |