If a person receiving a solid organ transplant is seronegative for hepatitis B, they are recommended to receive hepatitis B vaccine before transplantation. This is because they may be at increased risk of infection from the transplanted organ.

An accelerated vaccination schedule can be used. See Table. Accelerated hepatitis B vaccination schedules for people with imminent risk of exposure in Vaccines, dosage and administration.

The combination hepatitis A-hepatitis B vaccine may be appropriate for people who are about to receive a liver transplant if they are not immune to either disease. This is because they have an increased risk of hepatitis B and/or severe liver disease after hepatitis A and B. The combination hepatitis A-hepatitis B vaccine is usually given in 3 doses using Twinrix (720/20). See Table. Combination hepatitis A-hepatitis B vaccines.

For more details, see Hepatitis A and Vaccination for people who are immunocompromised.

Page history

Last updated: 
4 June 2018
Last reviewed: 
4 June 2018