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Table. Recommended doses and schedules for combination hepatitis A and hepatitis B vaccines

Vaccine Age of vaccine recipient (years) Dose (hepatitis A virus antigen) Volume per dose (mL) No. doses Vaccination schedule Notes
Twinrix Junior (360/10) 1 to <16 360 ELISA U 0.5 3
  • 1st dose: day 0 (day of vaccination)
  • 2nd dose: 1 month after 1st dose
  • 3rd dose: 6 months after 1st dose
 None
Twinrix (720/20) 1 to <16 720 ELISA U 1.0 2
  • 1st dose: day 0 (day of vaccination)
  • 2nd dose: 6–12 months after 1st dose
 Do not use this schedule for people who need rapid protection against hepatitis B (eg a close contact of a person with chronic hepatitis B)
Twinrix (720/20) ≥16 720 ELISA U 1.0 3
  • 1st dose: day 0 (day of vaccination)
  • 2nd dose: 1 month after 1st dose
  • 3rd dose: 6 months after 1st dose
 None
Twinrix (720/20) ≥16 720 ELISA U 1.0 4
  • 1st dose: day 0 (day of vaccination)
  • 2nd dose: 7 days after 1st dose
  • >3rd dose: 21 days after 1st dose
  • >4th dose: 12 months after 1st dose
 Only use this accelerated schedule if there is very limited time before travel to either moderately or highly endemic regions. See also Table. Accelerated hepatitis B vaccination schedules for people with imminent risk of exposure
For more details on combination hepatitis A/hepatitis B vaccines and schedules, see Hepatitis B.
Related diseases
Hepatitis A
Hepatitis B

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