Table. Vaccination for people with inborn errors of immunity: live vaccines
Live vaccine | Antibody (B-cell) immunodeficiency | T-cell or combined (T- and B-cell) immunodeficiency | Phagocytic and neutrophil disorder | Defect of innate immunity | Complement deficiency |
---|---|---|---|---|---|
BCG | Contraindicated | Contraindicated | Contraindicated | Contraindicated, or consult a specialist | Use if indicated |
Cholera (live) | Contraindicateda | Contraindicateda | Contraindicateda | Contraindicateda | Use if indicated |
Japanese encephalitis (live) | Contraindicateda | Contraindicateda | Contraindicateda | Contraindicateda | Contraindicated |
Measles-mumps-rubellab | Contraindicated, except for partial antibody deficiency with known intact T-cell immunity | Contraindicated, except for partial T-cell or combined deficiencies with a CD4+ count >500 cells/μL and normal mitogen response | Generally contraindicated, except for chronic granulomatous disease | Contraindicated, except for IFN-gamma/IL-12 axis defects | Follow routine schedule |
Q fever | Contraindicated, or consult a specialist | Contraindicated, or consult a specialist | Contraindicated, or consult a specialist | Contraindicated, or consult a specialist | Use if indicated |
Rotavirus | Contraindicated | Contraindicated | Generally contraindicated, except for chronic granulomatous disease | Contraindicated, or consult a specialist | Follow routine schedule |
Typhoid (live) | Contraindicateda | Contraindicateda | Contraindicateda | Contraindicateda | Use if indicated |
Varicella (monovalent)b | Contraindicated, except for partial antibody deficiency with known intact T-cell immunity | Generally contraindicated, except for partial T-cell or combined deficiencies with a CD4+ count >500 cells/μL and normal mitogen response | Generally contraindicated, except for chronic granulomatous disease | Contraindicated, except for IFN-gamma/IL-12 axis defects | Follow routine schedule |
Yellow fever | Contraindicated, or consult a specialist | Contraindicated, or consult a specialist | Generally contraindicated, except for chronic granulomatous disease | Contraindicated, or consult a specialist | Use if indicated |
Acronyms used:
Footnotes: a If indicated for use, choose the non-live vaccine option. b Measles-mumps-rubella-varicella combination vaccines are not recommended. |
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